QUOTE (Alan @ 2-14-08, 7:41pm)
Where does the file actually reside? Is it on your local hard drive or on a system accessed via the VPN? If it's a very large file it could be taking a long time to save over the VPN. If this is the case I would download the file, work on it locally, save it and upload it to the system it needs to reside on. I don't know what type of broadband service you have or what your download/upload speeds are, but keep in mind that typical download speeds are from 3Mbps-6Mbps where typical upload speeds are 300kbps-700kbps.
If it's already a file saved locally on your hard drive try defragmenting the system and see if that helps.
By the way, what's the size of the excel file?
I am getting the same feeling like Alan. Given this is via a VPN and you mentioned large excel files (I'm guessing at least a few megs). What happens when you open a file is that it's cached in your memory. When you call save, it overwrites the existing file by flushing it out from the memory. So every time you try to save, it's uploading that few MB file which even a good broadband connection can take upto a minute.
As others have suggested, there are several work arounds:
* Create a local copy, then upload when you're done.
* Instead of running Excel on your local machine, you can remote (VNC, Remote Desktop, etc) into the box that has the file and use Excel from that machine. That way only display information is sent and not the actual file.